BumFreezeno it wont jitter. high dpi low sens is better because your mouse is measuring in smaller resolutions, as opposed to just multiplying up your mouse inputs (which is what causes the skipping you mentioned)
I want to expand upon this.
The best scenario is one where your in-game sensitivity doesn't actually change the incoming value. What I mean by this is any multiplication or division done on your sensitivity will cause some loss of precision between your mouse movement and the movement on screen.
Unfourtunately, modern mice don't have resolutions high enough to make cl_yaw 1; sensitivity 1; feasible. So, my general rule of thumb to reduce this loss in precision as much as possible is to keep cl_yaw default, and set sensitivity to 1 - then change your DPI to compensate.
For example, I currently use a 10.9"/360 sensitivity - at 500 DPI thats 3 in-game sensitivity. Dividing sens by 3 gives me 1, and balancing out my DPI by multiplying it by 3 gives me 1500 DPI.
Is the difference in precision noticeable? Probably not. But, I'm stupid and like to use "optimal" settings even when it really doesn't matter.