Generally no, you can have 2 different HUD crosshairs using minmode and different HUD crosshairs for each class using achievement tracker crosshairs (which is too complicated in my opinion).

minmode
net_graph
achievement tracker
class portrait

can all be used to have different crosshairs

net graph? how does that work

I can't see net_graph helping, unless you are using an Ambassador script that turns on net_graph when the gun is cooling off, and it turns it off when it's ready to headshot again. Which is pretty ridiculous.

I'd assume the same way as the others except in the net_graph file (don't know what file off the top of my head but you could find it by searching for that edit which makes the text smaller).
Problem is you'd either have to disable the graph or have it turning off and on with your crosshair.

Couldn't do that without wait probably, also having a toggleable crosshair that doesn't lag (changing minmodes) is fairly useful, however most players do use netgraph while they're playing. Anyway if you are looking to mess with it look for sourcescheme.res

That's why people are using hudachievementtracker for it, since Minmode freezes like reloadscheme. Plus, net_graph has a delay (doesn't freeze the screen, though), and sometimes when playing Spy and checking scoreboard, it doesn't go away until 4 seconds later.